ParkinsonCanadaV1, Main, Exploration, bibRecord, 002B37

Corpus callosum in neurodegenerative diseases : Findings in Parkinson's disease

Identifieur interne : 002B37 ( Main/Exploration ); précédent : 002B36; suivant : 002B38

Corpus callosum in neurodegenerative diseases : Findings in Parkinson's disease

Auteurs : Katie Wiltshire [Canada] ; Sheri Foster [Canada] ; Jeffrey A. Kaye [États-Unis] ; Brent J. Small [États-Unis] ; Richard Camicioli [Canada]

Source :

Dementia and geriatric cognitive disorders [ 1420-8008 ] ; 2005.

RBID : Pascal:06-0002537

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Démence, Trouble cognition, Parkinson maladie, Maladie dégénérative, Corps calleux, Imagerie RMN.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (pathology), Atrophy, Cognitive disorder, Corpus Callosum (pathology), Corpus callosum, Degenerative disease, Dementia, Dementia (complications), Dementia (pathology), Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Nervous system diseases, Neurodegenerative Diseases (pathology), Nuclear magnetic resonance imaging, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Severity of Illness Index, Supranuclear Palsy, Progressive (pathology).
MESH :
- complications : Dementia, Parkinson Disease.
- pathology : Alzheimer Disease, Corpus Callosum, Dementia, Neurodegenerative Diseases, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Atrophy, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Severity of Illness Index.

Abstract

Corpus callosum area has been examined in neurodegenerative diseases as a marker for cortical pathology and for differential diagnosis; however, it has not been examined in Parkinson's disease (PD). We compared callosal area in patients with PD and PD with dementia (PDD) to healthy controls and patients with Alzheimer's disease (AD). We subsequently compared our results to a meta-analysis of studies examining callosal area in AD, frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). For the imaging study, midsagittal T₁-weighted MRIs were analyzed and the callosal area was determined in patients with PD (n = 24), PDD (n = 25), AD (n = 16) and controls (n = 27). The meta-analysis combined results from all publications (Medline or PubMed) representing unique samples and measuring callosal area in AD, FTD, PSP, and CBD. We found that PD and PDD patients did not show statistically significant callosal atrophy compared to controls (effect size d, 95% Cl, d = 0.13, -0.26 to 0.52, and d = 0.05, -0.44 to 0.33, respectively) or AD. The AD patients had a significant loss of callosal area compared to controls (d = -0.58, -1.01 to -0.15). Dementia severity was correlated with total callosal atrophy in AD (R = 0.66, p < 0.01) but not in PDD patients (R = 0.18, p> 0.1). The meta-analysis revealed significant combined effect sizes for callosal atrophy of: AD (d = -1.03, -1.13 to -0.93), FTD (d = -1.21, -1.56 to - 0.86), PSP (d = -1.09, -1.38 to -0.81), and CBD (d = -1.80, -2.18 to -1.43). We conclude that PD and PDD patients do not have callosal atrophy in contrast to other neurodegenerative diseases, including AD. Callosal atrophy was correlated with dementia severity in patients with AD but not PDD.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Corpus callosum area has been examined in neurodegenerative diseases as a marker for cortical pathology and for differential diagnosis; however, it has not been examined in Parkinson's disease (PD). We compared callosal area in patients with PD and PD with dementia (PDD) to healthy controls and patients with Alzheimer's disease (AD). We subsequently compared our results to a meta-analysis of studies examining callosal area in AD, frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). For the imaging study, midsagittal T<sub>1</sub>
-weighted MRIs were analyzed and the callosal area was determined in patients with PD (n = 24), PDD (n = 25), AD (n = 16) and controls (n = 27). The meta-analysis combined results from all publications (Medline or PubMed) representing unique samples and measuring callosal area in AD, FTD, PSP, and CBD. We found that PD and PDD patients did not show statistically significant callosal atrophy compared to controls (effect size d, 95% Cl, d = 0.13, -0.26 to 0.52, and d = 0.05, -0.44 to 0.33, respectively) or AD. The AD patients had a significant loss of callosal area compared to controls (d = -0.58, -1.01 to -0.15). Dementia severity was correlated with total callosal atrophy in AD (R = 0.66, p < 0.01) but not in PDD patients (R = 0.18, p> 0.1). The meta-analysis revealed significant combined effect sizes for callosal atrophy of: AD (d = -1.03, -1.13 to -0.93), FTD (d = -1.21, -1.56 to - 0.86), PSP (d = -1.09, -1.38 to -0.81), and CBD (d = -1.80, -2.18 to -1.43). We conclude that PD and PDD patients do not have callosal atrophy in contrast to other neurodegenerative diseases, including AD. Callosal atrophy was correlated with dementia severity in patients with AD but not PDD.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Corpus callosum in neurodegenerative diseases : Findings in Parkinson's disease

Corpus callosum in neurodegenerative diseases : Findings in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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